Personal Health

Why more men die on the Coronavirus as women

The number of Infected and deaths from the Coronavirus from China continues to increase worldwide. In addition to China, other countries, such as Iran, South Korea and Italy to pay sudden increases in the case. Alone in the Northern Italian Region of Lombardy there are 165 proven infections with the Coronavirus (medical Name “Sars-CoV-2”) – […]

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How new loops in DNA packaging help us make diverse antibodies: A study ties together chromatin loops and V(D)J recombination to explain how the immune system achieves antibody diversity

Diversity is good, especially when it comes to antibodies. It’s long been known that a gene assembly process called V(D)J recombination allows our immune system to mix and match bits of genetic code, generating new antibodies to conquer newly encountered threats. But how these gene segments come together to be spliced has been a mystery. […]

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A novel T-cell subset associated with type 1 diabetes

A study conducted at the University of Eastern Finland demonstrated that a recently described T-cell subset, so-called peripheral T helper cells, may have a role in the development of type 1 diabetes. The frequency of circulating peripheral T helper cells was observed to be increased both in children with recently diagnosed type 1 diabetes and […]

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Leishmania virulence strategy unveiled

A team from the Institut National de la Recherche Scientifique (INRS) has made a scientific breakthrough regarding the virulence strategy employed by the Leishmania parasite to infect cells of the immune system. This microorganism is responsible for Leishmaniasis, a chronic parasitic disease that affects more than 12 million people worldwide. The Leishmania parasite was already […]

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Deciphering pancreatic cancer’s invade and evade tactics

Two known gene mutations induce pathways that enhance pancreatic cancer’s ability to invade tissues and evade the immune system. Researchers report the molecular details of this process providing insights into druggable targets for immunotherapies. Mutations in the genes KRAS and TP53 are closely linked to pancreatic ductal adenocarcinoma, by far the most common type of […]

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New regulator of immune responses discovered

Scientists have identified a new internal regulator that helps control the body’s response to fight infection. The discovery could be a target for new drugs to tackle autoimmune diseases, such as lupus and scleroderma, where healthy tissues are attacked by the body’s own immune system. “We want to put a brake on the body’s own […]

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New strategy of reprogramming regulatory T cells may improve cancer therapies: Converting immunosuppressive cells into inflammatory cells appears to prime tumors for immune checkpoint blockade

While therapies that harness the power of the immune system against cancer have made remarkable progress against certain types of tumors, they still remain ineffective in most cancer patients. A new study from the Center for Immunology and Inflammatory Diseases (CIID) at Massachusetts General Hospital (MGH) describes a method of reprogramming the regulatory T cells […]