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Early results from a UCLA-led clinical trial found treating women with estrogen receptor (ER)-positive and human epidermal growth factor receptor-2 (HER2)-negative early breast cancers with a novel type of anti-hormonal therapy, called an oral selective estrogen receptor degrader (SERD), led to clinically meaningful reductions in tumor activity prior to surgery. The activity was assessed by measuring the […]
New findings by researchers at Yale Cancer Center show the drug combination of nivolumab and rucaparib shows clinical activity for patients with chemotherapy-naïve, metastatic castration resistant prostate cancer (mCRPC). The findings are part of the CheckMate 9KD trial and will be presented on September 19, 2021, at the annual meeting of the European Society for […]
An antioxidant drug reverses atherosclerosis and could be used to prevent heart attacks and strokes due to clots, according to research funded by the British Heart Foundation (BHF) and published today in JAHA: Journal of the American Heart Association. Atherosclerosis is the build-up of fatty deposits in the arteries. When a type of fat called […]
Gastrointestinal stroma tumors (GIST) are cancers that start in specialized nerve cells found in the digestive system, from the esophagus and stomach to the intestines and rectum. They are rare, but because they often grow slowly or initially cause no symptoms, GIST can be problematic to detect and treatment options are limited to a handful […]
Babies born with the rare, inherited motor neuron disease spinal muscular atrophy are, without treatment, unlikely to reach their second birthday. When, as a researcher in the 1990s, I became aware of the disease there were no treatments even on the horizon. Now there are two recently licensed drugs to treat this devastating affliction. There […]
Post-traumatic stress disorder (PTSD) is prevalent in today’s society. Medical researchers have been seeking solutions to combat this condition and its manifestations. Unfortunately, the neurological mechanisms of PTSD aren’t clear. A group of Japanese researchers from the Sogo PTSD Institute, Medical Corporation Sogokai, Japan, led by Dr. Masanobu Sogo, appear to have made a breakthrough […]
Cancer immunotherapy involving drugs that inhibit CTLA-4 also activates an unwanted response that may self-limit its efficacy in fighting tumors, according to a new study led by Francesco Marangoni, Ph.D., assistant professor of physiology & biophysics and member of the Institute for Immunology at the University of California, Irvine. Study results are published online in […]
Illegal drug production on European soil increased during the coronavirus pandemic last year as lockdowns helped move drug sales from streets to encrypted online platforms, according to an analysis of continental drug trends released Wednesday. The 2021 European Drug Report says criminal groups also adapted to travel restrictions and border closures by relying less on […]
FDA approves first drug to treat Alzheimer’s patients since 2003 despite controversy over mixed clinical trial results On Monday, the FDA approved aducanumab, which was developed by Biogen Inc, to treat Alzheimer’s disease The drug removes amyloid beta proteins from the brain and could slow down patients’ cognitive decline Aducanumab is not only the first drug […]
Researchers at the University of Kentucky Center of Excellence in Rural Health (UK CERH) and the Walsh Center for Rural Health Analysis at the National Opinion Research Center (NORC) at the University of Chicago have released a report detailing the findings of a study conducted to understand possible factors that contribute to Eastern Kentucky leading […]