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Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-β (Aβ) fibrillation and plaque formation. While more than 50 million people are devastated by AD, no treatment is available. Recently, anti-Aβ antibody-based immunotherapy has failed in clinical trials, partially due to the increased cytotoxicity of soluble Aβ oligomers. Therefore, developing a medication for AD […]
Red meat IS bad for you: Eating pork or beef twice a week raises the risk of heart disease by up to 7%, according to study of 30,000 people Almost 30,000 people were followed for up 30 years by US researchers Two portions of red or processed meat raised premature death risk by 3% Red […]
Patients with nonalcoholic steatohepatitis (NASH), a chronic liver disease and a leading cause for liver transplantation in the U.S., currently lack an approved drug therapy, but this may soon change. A large Phase III clinical trial designed in collaboration with Virginia Commonwealth University is the first to demonstrate the safety and effectiveness of an oral […]
A company that claims to have the first drug to slow mental decline from Alzheimer’s disease made its case to scientists Thursday, disclosing more results that may help explain why one study of the experimental medicine succeeded and another failed. Excitement and skepticism have surrounded aducanumab since its developers stopped studies earlier this year because […]
Higher exposure to commonly used oral antibiotics is linked to an increased risk of Parkinson’s disease according to a recently published study by researchers form the Helsinki University Hospital, Finland. The strongest associations were found for broad spectrum antibiotics and those that act against against anaerobic bacteria and fungi. The timing of antibiotic exposure also […]
New insights into the journey from health to disease in the human liver have been made by scientists at the Wellcome Sanger Institute, Cancer Research UK Cambridge Institute, the University of Cambridge and their collaborators. In the largest study of its kind, the team documented in unprecedented detail how the accumulation of changes in our […]
Hereditary and relatively common, polycystic kidney disease (PKD) has long been thought to be progressive and irreversible, condemning its sufferers to a long, slow and often painful decline as fluid filled cysts develop in the kidneys, grow and eventually rob the organs of their function. Once their kidneys fail, PKD patients often require dialysis several […]
In research that helps scientists better understand and explore treatments for diseases like Alzheimer’s, scientists have developed a line of mice in which the mouse version of the Alzheimer’s-associated MAPT gene has been fully replaced by the human version of the gene. In this new animal model, known as a full gene-replacement model, the MAPT […]
(HealthDay)—The number of cases of Legionnaires’ disease tied to the North Carolina Mountain State fair has risen to 25, with one death, according to the state division of public health. The cause of the outbreak is still being investigated, but many of those sickened went to the fair in Fletcher between Sept. 6 and 15, […]
Research published today in the journal Circulation has found that women with high blood pressure in pregnancy, including conditions such as preeclampsia, have an increased risk of developing cardiovascular disorders later in life, including stroke and heart failure. Led by King’s College London, the team of researchers studied electronic health records from 1997 to 2016 […]