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The Ivy Brain Tumor Center at Barrow Neurological Institute, the largest early-phase drug development program for brain cancer in the world, announced results from their Phase 0/1 clinical trial of ribociclib plus everolimus in patients with high-grade glioma (HGG). The study found that ribociclib achieved pharmacologically-relevant concentrations in gadolinium (Gd)-non-enhancing tumor, consistent with the observed […]
A large study of brain MRI scans from 11,679 nine- and ten-year-old children reviewed by UC San Francisco neuroradiologists identified potentially life-threatening conditions in 1 in 500 children, and more minor but possibly clinically significant brain abnormalities in 1 out of 25 children. The results provide the best estimates to date of the true incidence […]
Endoscopic endonasal brain surgery is a minimally invasive technique that is associated with reduced recovery times compared with traditional techniques such as craniotomy. The total amount of time required to recover following this procedure will vary by; tumor location areas of the brain affected by surgery age and general health of the patient whether the […]
A drug used to treat chronic myeloid leukemia appears to be more effective at stopping a type of medulloblastoma in mouse models than existing treatments for the deadly pediatric brain tumor, reports a multi-institutional team led by researchers at Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California San Diego. In the study, […]
University of Delaware molecular biologist Mona Batish and collaborators at Harvard Medical School and University of California, Los Angeles, have identified a new circular ribonucleic acid (RNA) that increases tumor activity in soft tissue and connective tissue tumors. Finding this new genetic unit has the potential to advance understanding of the genetics of cancer and […]
A new study using mass spectrometry is helping piece together what happens when DNA that has been sensitized by the oncology drug 5-fluorouracil is subjected to the ionising radiation used in radiotherapy. The anti-cancer drug 5-fluorouracil (5FU) acts as a radiosensitizer: it is rapidly taken up into the DNA of cancer cells, making the cells […]
Rhythms in gene expression in the brain are highly disrupted in people with schizophrenia, according to a new University of Pittsburgh-led study. The findings, published today by researchers from the Pitt’s School of Medicine in the journal Nature Communications, also suggest that researchers studying schizophrenia-linked genes in the brain could have missed important clues that […]
New data suggest that people who have a parent, sibling, or child with blood cancer have a higher likelihood of being diagnosed with the disease. The study published online today in Blood offers the first evidence that such familial risks exist across the spectrum of hematologic malignancies. Age of diagnosis, whether the relative is a […]
Two known gene mutations induce pathways that enhance pancreatic cancer’s ability to invade tissues and evade the immune system. Researchers report the molecular details of this process providing insights into druggable targets for immunotherapies. Mutations in the genes KRAS and TP53 are closely linked to pancreatic ductal adenocarcinoma, by far the most common type of […]
Neurodevelopmental disorders arising from rare genetic mutations can cause atypical cognitive function, intellectual disability, and developmental delays, yet it is unclear why and how this happens. Scientists suspected a mutation in a complex of proteins could be the culprit for a group of rare genetic disorders and, now, Salk Institute researchers have identified the molecular […]