Health Problems

Gaucher's Disease Genetics

Gaucher's disease is a genetic condition that affects various different tissues and organs in the body. Several forms of this condition have been identified based on the specific features of the disease and the signs and symptoms vary between affected individuals. Gaucher's disease is caused by a deficiency in the enzyme beta-glucocerebrosidase. This deficiency leads […]

Health Problems

Cetuximab Side Effects

Cetuximab is a monoclonal antibody used in the treatment of cancer. The agent targets and binds to epidermal growth factor receptors, inhibiting it its ability to send signals to cancer cells that promote tumor growth, angiogenesis and survival. Cetuximab is approved for use in metastatic colorectal cancer and head and neck cancer. Some of the […]

Health Problems

Hepatitis B Prevention

The hepatitis B virus (HBV) is spread when contact is made with blood and bodily fluids contaminated with HBV. Several measures can be taken to prevent the spread of hepatitis B and some of these are described below. Routine screening of blood and blood products such as fresh frozen plasma and platelets before transfusions. Since […]

Health Problems

What is Epilepsy?

Epilepsy is a condition that has been known to mankind since ancient times. It affects the brain to cause repeated convulsions or seizures – also called fits in common parlance. The word “epilepsy” comes from the Greek and means to be taken, seized or attacked. Who does epilepsy affect? Epilepsy affects more than 500,000 people […]

Health Problems

Barbiturate Mechanism

Barbiturates may have been abandoned as sedatives and tranquillizers due to their high abuse and dependence potential and risk of side effects, but they continue to hold an important place in neurology practice today. There are several uses of these agents and at present there are two major uses – as an agent that induces […]

Health Problems

ADHD and Asperger's

Attention deficit hyperactivity disorder (ADHD) and Asperger’s disorder were considered to be two distinct psychiatric conditions. Asperger’s disorder, like other conditions in the autism spectrum, is characterized by significant lack of social interaction, communication, and limited behavior patterns, with seriously restricted interests and activities. However, it is now considered to be the same condition as […]

Health Problems

What is Cardiomyopathy?

Cardiomyopathy is a disease of the heart muscles which may cause them to become enlarged and inflamed. Inflamed muscles become stretched, weak, less efficient at pumping blood and less able to maintain a normal electrical pattern. This can eventually lead to heart failure. While patients with mild cardiomyopathy may lead a near-normal life, those with […]

Health Problems

What is Lowe's Syndrome?

Lowe’s syndrome – also known as the cerebrooculorenal syndrome, the oculocerebrorenal syndrome of Lowe, and phosphatidylinositol-4,5-bisphosphate-5-phosphatase deficiency – represents a very rare multisystem disorder that affects the eye, the central nervous system, and the kidneys. The condition was initially described in 1952 by Lowe and his colleagues as a potpourri of hydrophthalmos, mental retardation, organic […]

Health Problems

Olanzapine Pharmacology

Olanzapine (2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine) is a second generation (also called “atypical”) antipsychotic agent related to clozapine. It has a complex pharmacology, interacting with the D1 and D2 dopamine receptors, multiple serotonin receptors, histamine receptors, as well as muscarinic cholinergic receptors. Olanzapine blocks serotonin receptors more strongly than dopamine receptors, which is a proposed mechanism for effects on […]

Health Problems

How Paclitaxel Works

Cancerous tumor cells are characterized by their rapid rate of cell division, which is no longer controlled as in normal tissues. Somatic cells of the body normally undergo a resting period during the G0 phase of the mitosis, and differentiate into functional cells no longer capable to divide. In case of active tumors, the cells […]