Health News

Leishmania virulence strategy unveiled

A team from the Institut National de la Recherche Scientifique (INRS) has made a scientific breakthrough regarding the virulence strategy employed by the Leishmania parasite to infect cells of the immune system. This microorganism is responsible for Leishmaniasis, a chronic parasitic disease that affects more than 12 million people worldwide. The Leishmania parasite was already […]

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Deciphering pancreatic cancer’s invade and evade tactics

Two known gene mutations induce pathways that enhance pancreatic cancer’s ability to invade tissues and evade the immune system. Researchers report the molecular details of this process providing insights into druggable targets for immunotherapies. Mutations in the genes KRAS and TP53 are closely linked to pancreatic ductal adenocarcinoma, by far the most common type of […]

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New regulator of immune responses discovered

Scientists have identified a new internal regulator that helps control the body’s response to fight infection. The discovery could be a target for new drugs to tackle autoimmune diseases, such as lupus and scleroderma, where healthy tissues are attacked by the body’s own immune system. “We want to put a brake on the body’s own […]

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New strategy of reprogramming regulatory T cells may improve cancer therapies: Converting immunosuppressive cells into inflammatory cells appears to prime tumors for immune checkpoint blockade

While therapies that harness the power of the immune system against cancer have made remarkable progress against certain types of tumors, they still remain ineffective in most cancer patients. A new study from the Center for Immunology and Inflammatory Diseases (CIID) at Massachusetts General Hospital (MGH) describes a method of reprogramming the regulatory T cells […]

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Fishing for cures: New zebrafish model identifies drugs that kill pediatric cancer cells

A new animal model developed by Massachusetts General Hospital (MGH) investigators promises to be less expensive, easier to use and to improve personalized therapies for cancers and potentially other diseases. In their paper published online in Cell, the investigators describe using their immunodeficient zebrafish model to visualize drug responses at single-cell resolution in live animals. […]

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Experimental drug delivers one-two punch to vision loss: Experiments show new therapy slows blood vessel leakage associated with diabetic macular edema and macular degeneration

In studies with lab-grown human cells and in mice, Johns Hopkins Medicine researchers have found that an experimental drug may be twice as good at fighting vision loss as previously thought. The new research shows that the compound, named AXT107, stops abnormal blood vessels in the eye from leaking vision-blocking fluids. These results build on […]

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Food additive may influence how well flu vaccines work

Michigan State University scientists have linked a common food preservative to an altered immune response that possibly hinders flu vaccines. The study conducted in mice, presented at the 2019 Experimental Biology meeting in Orlando, Fla., April 7 at 9 a.m., offers up a new potential factor in vaccine effectiveness. Tert-butylhydroquinone, or tBHQ, can be found […]

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How do muscle and tendon connections last a lifetime? Cell biologists show in fruit flies how a protein controls mechanical stress on muscle-tendon attachments

Muscles are connected to tendons to power animal movements such as running, swimming or flying. Forces are produced by contractile chains of the proteins actin and myosin, which are pulling on muscle-tendon connections called attachments. During animal development, these muscle-tendon attachments must be established such that they resist high mechanical forces for the entire life […]